Jason Cranford Teague Prototyping a Responsive Design
Jason Cranford goes into detail about his journey from the humble wireframe to changing his workflow to use HTML & CSS to wireframe directly within the browser. This contains both the podcast and transcript.
With the emergence of techniques like responsive web design, many of the traditional prototyping methods become difficult to employ. Sketches and wireframes have in some cases given way to HTML and CSS prototyping so that users and clients can experience a richer, more complete interaction.
An excerpt from Jason Cranford Teague Prototyping a Responsive Design